目的 考察卡波姆等生物黏附材料的体内外黏附性能,全面评价材料的生物黏附特性。方法 以猪胃黏蛋白模型、自制黏附力测定装置及小鼠肠推进模型,综合评价材料的体内生物黏附性。结果 卡波姆中以卡波姆934P体内黏附性能最优,羟丙基甲基纤维素以高黏度HPMCK100M最优,壳聚糖能够与猪胃黏蛋白发生特异性结合,其体内黏附性能优于大部分黏附材料。结论 同种材料中,材料的生物黏附性能与材料的黏度呈正相关,不同种类的材料在评价时除黏度外还应考虑材料的相对分子质量、吸湿性能及与黏蛋白特异性结合的能力等因素,进行综合评价。
Abstract
OBJECTIVE To comprehensively evaluate bioadhesive properties these materials by testing adhesion properties in vitro and in vivo.METHODS Mucin from porcine stomach model,homemade adhesion measuring device and intestinal propulsion were used for in vitro and in vivo evaluation adhesive materials.RESULTS Carbomer 934P and HPMCK100M with high viscosity had optimal adhesion in their class, besides chitosan can be specifically bound by mucin from porcine stomach and it performed better than other materials in vivo adhesion.CONCLUSION Above researches indicate that the bioadhesive properties had a positive correlation with viscosity in the same type material,and the relative molecular mass the materials, moisture absorption capacity,specific binding mucin and other factors should be considered in different types materials in the comprehensive evaluation.
关键词
猪胃黏蛋白 /
肠黏附力 /
肠推进 /
生物黏附 /
卡波姆 /
壳聚糖
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Key words
porcine stomach mucin /
intestinal adhesion /
intestinal propulsion /
bioadhesion /
carbomer /
chitosan
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中图分类号：
R944
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参考文献
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脚注
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基金
国家科技重大专项(2014ZX09301306-008);北京中医药大学科研创新团队项目(2011-CXTD-13);北京中医药大学自主选题项目(2014-JYBZZ-XS-112)
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